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Prof. Antônio Eduardo Miller Crotti

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Antonio Eduardo Miller Crotti studied Chemistry at the University of Franca. In July 1999, he got an internship as a volunteer at the Laboratory of Organic Synthesis (LOS). In 2001 and 2005, respectively, he finished his MSc and Ph.D. studies under the supervision of Prof. João Luis Callegari Lopes at the University of São Paulo.  His MSc and Ph.D. projects focused on the isolation and structural elucidation of Natural Products from plants and mass spectrometry, respectively. From March 2005 to May 2013, prof. Miller was a researcher at the Research Group on Natural Products of the University of Franca (GPNUF), where he was the advisor of a dozen of graduate students.  In 2011, he came back to LOS as a post-doctoral fellow researcher under the supervision of prof. Paulo Marcos Donate. In 2013, prof. Miller started his teaching and research activities at the Department of Chemistry and relocated his group to LOS. From July 2018 to June 2019, prof. Miller was a visiting professor at the University of Victoria, BC, Canada for a sabbatical year under the supervision of prof. J. Scott McIndoe.  

          Currently, his research focuses on biologically active synthetic and natural products and on the application of mass spectrometry in the elucidation of organic compounds, gas-phase fragmentation reactions, and the investigation of organic reaction mechanisms.

       Prof. Miller loves studying and teaching organic chemistry. Outside the lab, he likes watching TV series, especially comedies, and spends his time with his children and wife. When prof. Miller is talking to someone, everyone in the lab can listen to his loud laughs, so it is easy to know when he is around.  

SOME SELECTED PUBLICATIONS

Souza, J. M.; Vieira, T. M.; Candido, A. C. B. B.; Tezykja, D. Y.; Rao, S.; Albuquerque, S.; Crotti, A. E. M.; Siqueira-Neto, J. L.; Magalhães, L. G. In vitro anti-Trypanosoma cruzi activity enhacement of curcumin by its monoketone tetramethoxy analog diveratralacetone. Current Research in Parasitology & Vector Borne Diseases 2021, 1, e10003. DOI: 10.1016/j.crpvbd.2021.100031

Crotti, A. E. M.; Previdi, D.; Donate, P. M.; McIndoe, J. S. Real-time monitoring of a cobalt-mediated one-pot transition metal-catalyzed multicomponent reaction. Inorganica Chimica Acta  2020508, 119654. DOI: 10.1016/j.ica.2020.119654.

Dias, H. J.; Crevelin, E. J.; Palaretti, V.; Vessecchi, R.; Crotti, A. E. M.* Electrospray ionization tandem mass spectrometry of deprotonated dihydrobenzofuran neolignans. Rapid Communications in Mass Spectrometry 202135, e8990. DOI: 10.1002/rcm.8990

Conceição, J. C. S.; Vieira, T. M.; Crotti, A. E. M.; Anjos, J. P.; Chagas-Paula, D. A.; Vieira, A. A.; Silva, E. O. Aspergillus brasiliensis-mediated biotransformation of methyl p-coumarate via phenyloxiran moiety: A predictive model for environmental bioremediation. International Biodeterioration & Biodegradation 2021158, 105167. DOI: 10.1016/j.ibiod.2020.105167 

 Dias, H. J.; Rodrigues, M. L.; Crotti, A. E. M. Optimization of the reaction conditions for the synthesis of dihydrobenzofuran neolignans. Journal of the Brazilian Chemical Society 2021, 32, 20-28. DOI: 10.21577/0103-5053.20200149​

Crotti, A. E. M.*; Previdi, D.; Donate, P. M.; McIndoe, J. S. Real-time monitoring of a cobalt-mediated one-pot transition metal-catalyzed multicomponent reaction. Inorganica Chimica Acta  2020508, 119654. DOI: 10.1016/j.ica.2020.119654.

Sousa, I. P.; Ferreira, A. G.; Crotti, A. E. M.; Santos, R. A.; Kiermaier, J.; Krause, B.; Heilmanne, J.; Furtado, N. A. J. C. New antifungal ent-labdane diterpenes against Candida glabrata produced by microbial transformation of ent-polyalthic acid. Bioorganic Chemistry 2020, 95, 103560. DOI: 10.1016/j.bioorg.2019.103560

Marchioni, C.; Vieira, T. M.; Crotti, A. E. M.; Crippa, J. A.; Queiroz, M. E. C. In-tube solid-phase microextraction with a dummy molecularly imprinted monolithic capillary coupled to ultra-performance liquid chromatography-tandem mass spectrometry to determine cannabinoids in plasma samples. Analytica Chimica Acta 2020, 1099, 145-154. DOI: 10.1016/j.aca.2019.11.017

Baldin, E. L. L.; Dias, H. J.; Souza, C. M.; Soares, M. C. E.; Grundmann, C. O.; Santos, T. L. B.; Crotti, A. E. M. Insecticidal and inhibitory effects of dihydrobenzofuran neolignans on Bemisia tabaci. Journal of Pest Science 2019, 92, 861-869. DOI:10.1007/s10340-018-1053-2

Crevelin, E. J.; Possato, B.; Lopes, J. L. C.; Lopes, N. P.; Crotti, A. E. M. A precursor ion scan mode-based strategy for fast screening of polyether ionophores by copper-induced gas-phase radical fragmentation reactions. Analytical Chemistry 201789, 3929-3936. DOI: 10.1021/acs.analchem.6b02855

Demarque, D. P.; Crotti, A. E. M.; Vessecchi, R.; Lopes, J. L. C.; Lopes, N. P. Fragmentation reactions using electrospray ionization mass spectrometry: an important tool for the structural elucidation and characterization of synthetic and natural products. Natural Product Reports 201633, 432-455. DOI: 10.1039/C5NP00073D

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